Diclofenac is a nonsteroidal anti-inflammatory drug (NSAID) of the phenylacetic acid class with anti-inflammatory, analgesic, and antipyretic properties. Contrary to the action of many traditional NSAIDs, diclofenac inhibits cyclooxygenase (COX)-2 enzyme with greater potency than it does COX-1. Similar to other NSAIDs, diclofenac is associated with serious dose-dependent gastrointestinal
For both the ibuprofen/levomenthol and the diclofenac gels, this was shorter (20.0 minutes) than that for the ibuprofen gel (25.0 minutes), indicating that the ibuprofen/levomenthol gel and the diclofenac gel were faster acting. However, the median time to significant pain relief was less than 30 minutes for all three gels. The NSAIDs that had consistently higher cardiovascular risks (RRs) were rofecoxib, etoricoxib, and diclofenac. All were found to have a higher RR than naproxen in pairwise analyses in the most recent published meta-analysis . Indometacin and meloxicam had moderately elevated RR values that were significantly greater than naproxen . Because the IC 50 of diclofenac is approximately 900 times lower than that of ibuprofen, cumulative absorption of ibuprofen-containing formulations would need to be 700 times greater than that of diclofenac products to compensate for this difference and achieve comparable anti-inflammatory activity. According to Fick’s law, for ibuprofen Go back to your gp explain everything you said snd see what they can offer. Instead of co-codamol ask for codeine phosphate = a stronger dose of codeine. You can keep your tens machine on all day. Lots of warm baths too and try a heated beanbag as they are longer than the cushions and mould around your tummy more. Although the efficacy of celecoxib compared with diclofenac and naproxen in relieving pain and improving physical function in patients with OA has previously been established, 16 –21 to date there has been little direct evidence comparing celecoxib with ibuprofen, despite ibuprofen being one of the most commonly used NSAIDs. eVKZgD.
